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A randomized sequential cross-over trial evaluating five purportedly ICP-lowering drugs in idiopathic intracranial hypertension.
Headache
January 2025
Translational Brain Science, Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK.
Objective: To gain initial insight into the efficacy to lower intracranial pressure (ICP), side effects, and effects on cognition of five drugs commonly used to treat idiopathic intracranial hypertension (IIH).
Background: Limited clinical data exist for the treatment for IIH. Impaired cognition is recognized in IIH and can be exacerbated by medications.
Speciation of Potentially Carcinogenic Trace Nickel(II) Ion Levels in Human Saliva: A Sequential Metabolomics-Facilitated High-Field H NMR Investigation.
Metabolites
December 2024
Leicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK.
Since the biological activities and toxicities of 'foreign' and/or excess levels of metal ions are predominantly determined by their precise molecular nature, here we have employed high-resolution H NMR analysis to explore the 'speciation' of paramagnetic Ni(II) ions in human saliva, a potentially rich source of biomolecular Ni(II)-complexants/chelators. These studies are of relevance to the corrosion of nickel-containing metal alloy dental prostheses (NiC-MADPs) in addition to the dietary or adverse toxicological intake of Ni(II) ions by humans. Unstimulated whole-mouth human saliva samples were obtained from n = 12 pre-fasted (≥8 h) healthy participants, and clear whole-mouth salivary supernatants (WMSSs) were obtained from these via centrifugation.
View Article and Find Full Text PDFAssessment of Changes in Executive Functions and Attention of Cadets as a Result of Military Parachute Jumping.
Brain Sci
January 2025
Department of Biostructure, Wroclaw University of Health and Sport Sciences, 51-612 Wroclaw, Poland.
Objectives: This study analyzed the effects of parachute jump stress on the executive functions and attention of cadets. Executive functions, which includes processes such as attentional control and cognitive flexibility, are crucial for soldiers, especially in situations requiring rapid decision-making. Parachute jumping, as an intense stressor, mobilizes cognitive resources, which can lead to short-term improvements in executive functions.
View Article and Find Full Text PDFIs there a role for nutritional advice during breastfeeding for infant colic relief? A mixed-method study.
Heliyon
January 2025
The Centre for Nutritional Education and Lifestyle Management (CNELM) and Middlesex University, Berkshire, PO Box 3739, Wokingham, RG40 9UA, United Kingdom.
Objective: This study aimed to explore the extent and impact of maternal dietary change for colic relief in a cohort of breastfeeding women.
Method: A mixed-method non-sequential approach was devised, including a web-based survey (n = 66) and three semi-structured interviews.
Results: Most women (70 %) changed their diet while breastfeeding a baby with colic and perceived a positive impact on their babies (63 %).
Background: This study aimed to identify distinct trajectories of serum osmolality within the first 72 h for patients with sepsis-associated encephalopathy (SAE) in the MIMIC-IV and eICU-CRD databases and assess their impact on mortality and adverse clinical outcomes.
Methods: In this retrospective cohort study, patients with SAE from the MIMIC-IV database were included. Group-based trajectory modeling (GBTM) was used to categorize distinct patterns of serum osmolality changes over 72 h in ICU patients.
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