AI Article Synopsis
- The novel cycloalkyl-N-(4-chlorophenyl)-hydroxamic acids (2a-g) showed significant inhibitory effects on various cancers, particularly with compounds 2b, 2d, and 2e demonstrating the strongest activity against pancreatic and colon carcinomas.
- Compound 2e also exhibited notable anti-cytomegalovirus effects, although its toxicity was close to effective dosage levels.
- Compounds 2d and 2f demonstrated selective but modest activity against cytomegalovirus, with specific EC50 and selectivity index values indicating potential for further study.
Article Abstract
In vitro evaluation of the novel cycloalkyl-N-(4-chlorophenyl)-hydroxamic acids (2a-g) demonstrated that 2b,d,e exhibited rather marked inhibitory activity (IC50 = 7-10 microM) against pancreatic carcinoma, 2b-d against colon carcinoma, 2d against laryngeal carcinoma, and 2b,d against breast carcinoma. 2e showed the most pronounced anti-cytomegalovirus activity (EC50 = 1.5 and 0.8 microg mL(-1)) only at > or = 5-fold lower than the cytotoxic concentration. 2d and 2f showed modest, albeit selective, activity against cytomegalovirus (2d, EC50 = 7.3-8.9 microg mL(-1), selectivity index 7-10; 2f, EC50 = 7-13 microg mL(-1), selectivity index 10).
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