Effects of dietary composition and trace element status on fractional intestinal cadmium uptake is reviewed below. Fractional cadmium uptake is of fundamental importance for internal dose, related individual susceptibility to cadmium, induced renal damage and eventually bone disease. Diet composition with regard to macronutrients has some effects on cadmium bioavailability. Major determinants of intestinal cadmium uptake are however diet composition with regard to crude fibres and trace elements, especially iron. Deficiencies may increase intestinal cadmium uptake 5-8 times. Ultimate risk management would be not to raise crops on cadmium polluted soil. Provisionally, assurance of optimal trace element statusin persons exposed to cadmium is essential for risk reduction.
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Article Synopsis
- The rise in attention on preventing acute lymphocytic leukemia (ALL) in children highlights its prevalence and links it to various risk factors affecting gut microbiota development, such as breastfeeding practices and cesarean deliveries.
- Research indicates that iron deficiency anemia (IDA) and vitamin D deficiency can disrupt gut health, decrease beneficial gut bacteria like Firmicutes, and lead to insufficient butyrate levels, potentially increasing the risk of hematological cancers.
- IDA is also associated with heightened blood levels of cadmium, systemic inflammation, and decreased vitamin D synthesis, all of which could cumulatively contribute to genetic mutations that lead to the onset of ALL.
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