AI Article Synopsis
- - Moiramide B and andrimid are new antibiotics that inhibit bacterial fatty acid biosynthesis using a unique structure called pyrrolidinedione.
- - Research on these compounds showed that the fatty acid side chain can vary widely, which helps improve their physical and chemical properties.
- - The pyrrolidinedione part of the molecules has a limited structure-activity relationship, suggesting it's crucial for effectively binding to the target in bacteria.
Article Abstract
The pseudopeptide pyrrolidinedione natural products moiramide B and andrimid represent a new class of antibiotics that target bacterial fatty acid biosynthesis. Structure-activity relationship (SAR) studies revealed a high degree of variability for the fatty acid side chain, allowing optimization of physicochemical parameters, and a restricted SAR for the pyrrolidinedione group, indicating major relevance of this subunit for efficient target binding.
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| http://dx.doi.org/10.1016/j.bmcl.2004.12.002 | DOI Listing |
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