Diphenhydramine overdose in one of the frequent reported causes of acute poisoning. Patients with diphenhydramine overdose can present with central nervous system manifestations, anticholinergic manifestations and cardiovascular symptoms. The cardiovascular symptoms of diphenhydramine overdose include myocardial depression and refractory hypotension. Massive ingestions have been reported to cause myocardial depressant effect with widening of QRS complex and prolonged QT interval on electrocardiogram. We report an adolescent male with moderate diphenhydramine ingestion, who was found unresponsive with seizure like activity. Electrocardiogram on presentation showed wide complex tachycardia with right bundle branch block pattern and QT interval prolongation. These changes reverted to normal with treatment. Diphenhydramine overdose may occasionally result in prolongation of QT interval.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijcard.2003.10.051 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
[Analysis of Overdose-related Posts on Social Media].
Yakugaku Zasshi
December 2024
Division of Drug Informatics, Keio University Faculty of Pharmacy.
Article Synopsis
- Intentional overdoses (OD) of OTC and prescription drugs are increasingly becoming a global issue, and there’s a lack of social media-focused research on this topic.* -
- This study analyzed over 30,000 Japanese Twitter posts related to "OD" using advanced language processing techniques, identifying specific drug mentions and emotional tones.* -
- Findings indicated a significant correlation between negative emotions and OD incidents, highlighting the potential of social media surveillance in identifying high-risk individuals and shaping prevention efforts.*
Diphenhydramine Overdose: A Case Report and Topic Review of Prehospital Diagnosis and Treatment.
Cureus
October 2024
Emergency Medicine, Florida State University College of Medicine, Sarasota, USA.
Diphenhydramine (DPH), a readily available first-generation H1 receptor antihistamine, can have severe consequences when taken in excessive amounts and can lead to grave outcomes such as seizures, dysrhythmias, coma, and death. Recognizing the early signs and symptoms of DPH toxicity is crucial. Fortunately, fatal adult cases of DPH overdose are rare.
View Article and Find Full Text PDFEvolving trends of pharmaceutical poisonings associated with QRS complex prolongation.
Clin Toxicol (Phila)
September 2024
American College of Medical Toxicology, Phoenix, AZ, USA.
Introduction: Tricyclic antidepressants often cause drug-induced QRS complex prolongation in overdose but are now less commonly prescribed. We sought to determine, among a contemporary cohort of patients, the pharmaceuticals independently associated with QRS complex prolongation in acute overdose.
Methods: We performed secondary analysis of data from the Toxicology Investigators Consortium (ToxIC) Core Registry.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!