Cells in the inferior olive are the sole source of climbing fibers to the cerebellum. In this article, we review some of the discharge properties of olivary cells that are important for understanding its functional role in cerebellar processing. It is generally believed that climbing fiber input supplies the cerebellum with information related to movement errors in order to improve motor performance. As a whole, olivary properties are not consistent with this function. The properties are consistent with the hypothesis that the olive is important for associating arbitrary sensory stimuli with somatosensory events. Although such associations would not be useful for improving the accuracy of motor commands, they may be useful for organizing appropriate behaviors to cope with the predicted event.
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http://dx.doi.org/10.1080/14734220410018995 | DOI Listing |
Elife
December 2024
Université Paris Cité, CNRS, Saints-Pères Paris Institute for the Neurosciences, Paris, France.
Granule cells of the cerebellum make up to 175,000 excitatory synapses on a single Purkinje cell, encoding the wide variety of information from the mossy fibre inputs into the cerebellar cortex. The granule cell axon is made of an ascending portion and a long parallel fibre extending at right angles, an architecture suggesting that synapses formed by the two segments of the axon could encode different information. There are controversial indications that ascending axon (AA) and parallel fibre (PF) synapse properties and modalities of plasticity are different.
View Article and Find Full Text PDFAm J Bot
November 2024
Naturalis Biodiversity Center, Darwinweg 2, Leiden, 2333CR, The Netherlands.
Premise: This paper provides an overview of the wood anatomy of the dogbane family (Apocynaceae), reconstructs wood anatomical trait evolution, and links this evolution with woody growth-form transitions and floral and seed trait innovations across the family.
Methods: Over 200 published wood anatomical descriptions were revised, and original light microscopic sections were made and described for another 50 species. Changes in wood anatomical characters through time were visualized with ancestral state reconstructions.
bioRxiv
October 2024
Department of Neurobiology and Neuroscience Institute, The University of Chicago, Chicago, IL, USA.
Purkinje cell (PC) dendrites are optimized to integrate the vast cerebellar input array and drive the sole cortical output. PCs are classically seen as stereotypical computational units, yet mouse PCs are morphologically diverse and those with multi-branched structure can receive non-canonical climbing fiber (CF) multi-innervation that confers independent compartment-specific signaling. While otherwise uncharacterized, human PCs are universally multi-branched.
View Article and Find Full Text PDFSci Rep
November 2024
College of Physical Education, Ludong University, Yantai, 264025, Shandong, People's Republic of China.
G protein alpha q subunit (Gαq) can binds to the G protein-coupled receptor (GPCR) for signaling and is closely related to lipid metabolism. Endurance exercise is an effective means of combating acquired obesity and its complications, but the mechanisms by which endurance exercise modulates hereditary obesity and its complications are unknown. In this study, we achieved knockdown of Gαq in drosophila adipose tissue and skeletal muscle by constructing the Gαq-UAS-RNAi/Ppl-Gal4 and Gαq-UAS-RNAi/Mef2-GAl4 systems.
View Article and Find Full Text PDFProc Jpn Acad Ser B Phys Biol Sci
November 2024
Advanced Comprehensive Research Organization (ACRO), Teikyo University, Tokyo, Japan.
Neural circuits are initially created with excessive synapse formation until around birth and undergo massive reorganization until they mature. During postnatal development, necessary synapses strengthen and remain, whereas unnecessary ones are weakened and eventually eliminated. These events, collectively called "synapse elimination" or "synapse pruning", are thought to be fundamental for creating functionally mature neural circuits in adult animals.
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