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Effect of Lo Han Kuo (Siraitia grosvenori Swingle) on nasal rubbing and scratching behavior in ICR mice. | LitMetric

AI Article Synopsis

  • The study examined the effects of Lo Han Kuo (Siraitia grosvenori) on nasal rubbing and scratching behaviors in mice triggered by histamine and compound 48/80.
  • The extract and glycoside of Lo Han Kuo did not show significant effects immediately, even at high doses (1000 mg/kg), but repeated treatments revealed notable reductions in these behaviors after 4 weeks.
  • The research suggests that the improvement in nasal and skin behaviors is linked to the inhibition of histamine release through a mechanism that depends on mast cells.

Article Abstract

We studied the effect of Lo Han Kuo (Siraitia grosvenori Swingle) on histamine-induced nasal rubbing and compound 48/80-induced skin scratching behavior in ICR mice. An extract and glycoside (a complex of sweet components) of Lo Han Kuo were used in the study. Both the extract and glycoside caused no significant effect on nasal rubbing or scratching behavior, even at a dose of 1000 mg/kg when administered in a single dose. However, the effect of Lo Han Kuo became clear after repeated administration, and 300 and 1000 mg/kg of both extract and glycoside significantly inhibited nasal rubbing and skin scratching behavior after consecutive treatment for 4 weeks. Both the extract and glycoside inhibited the histamine release induced by compound 48/80 at concentrations of 300 and 1000 microg/ml. From these results, it is assumed that the inhibition of nasal rubbing and skin scratching behavior induced by Lo Han Kuo occurs through a mast cell-dependent mechanism.

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Source
http://dx.doi.org/10.1248/bpb.28.238DOI Listing

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