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Background: Accurate assessment of oxygen delivery relative to oxygen demand is crucial in the care of a critically ill patient. The central venous oxygen saturation (Svo) enables an estimate of cardiac output yet obtaining these clinical data requires invasive procedures and repeated blood sampling. Interpretation remains subjective and vulnerable to error.

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Background: Aneurysmal subarachnoid hemorrhage (aSAH) causes systemic changes that contribute to delayed cerebral ischemia (DCI) and morbidity. Circulating metabolites reflecting underlying pathophysiological mechanisms warrant investigation as biomarker candidates.

Methods: Blood samples, prospectively collected within 24 hours (T1) of admission and 7-days (T2) post ictus, from patients with acute aSAH from two tertiary care centers were retrospectively analyzed.

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Alpha and Theta Oscillations Associated With Behavioral Phenotypes of Pain-Attention Interaction.

Brain Behav

January 2025

Division of Brain, Imaging and Behavior, Krembil Brain Institute, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.

Purpose: Pain is inherently salient and so draws our attention in addition to impacting performance on attention-demanding tasks. Individual variability in pain-attention interactions can be assessed by two kinds of behavioral phenotypes that quantify how individuals prioritize pain versus attentional needs. The intrinsic attention to pain (IAP) measure quantifies the degree to which a person attends to pain (high-IAP) or mind-wanders away from pain (low-IAP).

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Glucagon-like peptides agonists promote maturation of intestinal organoids derived from neonates with necrotizing enterocolitis.

Pediatr Surg Int

January 2025

Department of General and Thoracic Surgery, The Hospital for Sick Children, University of Toronto, 1526-555 University Ave, Toronto, ON, M5G 1X8, Canada.

Purpose: Necrotizing enterocolitis (NEC) majorly affects premature infants, causing not only necrosis and inflammation but also feeding intolerance and gastrointestinal dysmotility, hinting at gut hormone secretion impairment. Particularly critical is the gestation period before 26 weeks where intestinal hormonal activity is partially developed, rendering preterm neonates highly susceptible to NEC. Emerging evidence suggests a role of gut hormones, especially glucagon-like peptides (GLP) in ileum development.

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Readiness to deliver quality curative care for under-five children at health posts in Ethiopia.

BMC Health Serv Res

January 2025

Department of Health Policy and Management, Faculty of Public Health, Jimma University, Jimma, Ethiopia.

Background: The institutionalization of village health services with salaried community health workers has been established in Ethiopia for over a decade. However, there are serious concerns about the capacity of health posts to provide quality curative care for children under-five.Understanding the readiness of health posts is crucial for improving the care given to sick children.

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