Two new lanostane triterpenoids (1, 2) and 10 new lanostane triterpene glycosides (3-12) have been isolated from the fruit bodies of Fomitopsis pinicola. Their structures were established primarily by NMR experiments and chemical methods, and their biological activity against COX-1 and COX-2 was investigated.
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Article Synopsis
- Eight new lanostane triterpenoids were discovered in Ganoderma cf. hochiminhense, including ganoboninketals G-K and other compounds.
- The structures of these compounds were determined using NMR spectroscopy and mass spectrometry techniques.
- Ganoboninketals G, H, and J showed significant antimalarial activity against a drug-resistant strain of Plasmodium falciparum, with IC values of 17, 16, and 5.1 μM, respectively.
Background: (), which possesses various biological effects, has been widely used as traditional medicine and functional food in Asian countries, especially China. In consideration of its various biological effects on human healthcare, . was usually used in combination with other drugs.
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