A 15-year-old man was incidentally found to have abnormal shadows in bilateral lungs on a chest X-ray film obtained at a school medical examination, and was referred to our hospital for a close investigation. Several lymph nodes were palpable in his cervical region. Chest X-ray and CT showed multiple and various sized nodules up to 20 mm in diameter in bilateral lung field. Abdominal CT showed multiple calcified lesions and low density areas in the liver. We performed video-assisted thoracoscopic lung biopsy, and diagnosed this case histologically as pulmonary epithelioid hemangioendothelioma. The tumor cells showed immunohistochemically positive staining for Factor VIII-related antigen that was one of endothelial cell marker. He has been followed up for 2 years and 11 months after the surgical lung biopsy without specific medication and remains asymptomatic at the time of writing this paper.
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