The authors reported the first case of leiomyomatosis peritonealis disseminata or diffuse peritonealis leiomyomatosis in a patient of 36 years old. The hyalin degeneration of leiomyomatosis with intra and extra peritonealis extension is an uncommon pathology. The right etiology of this complication of leiomyomatosis is unknown. Its detection is a fortuitous event during laparotomy. It is characterized by an extension to the serosa, a break-in of the tissues and unpredictable invasion of the contiguous organs, and it can touch the heart. Despite its rapid evolution, often accompanied by mechanical complications, it remains a benign tumour.
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