There are several types of experiment in which it is useful to have subjects speak overtly in a magnetic resonance imaging (MRI) scanner, including those studying the articulatory apparatus and the neural basis of speech production, and fMRI experiments in which speech is used as a response modality. Although it is relatively easy to record sound from the bore, it can be difficult to hear the speech over the very loud acoustic noise from the scanner. This is particularly a problem during echo-planar imaging, which is usually used for fMRI. We present a post-hoc sound cancellation algorithm, and describe a Windows-based tool that implements it. The tool is fast and operates with minimal user intervention. We evaluate cancellation performance in terms of the improvement in signal-to-noise ratio, and investigate the effect of the recording medium. A substantial improvement in audibility was obtained.
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http://dx.doi.org/10.1002/hbm.20085 | DOI Listing |
Fluids Barriers CNS
January 2025
Medical Image Processing Department, CHU Amiens-Picardie University Hospital, Amiens, France.
Background: The pressure gradient between the ventricles and the subarachnoid space (transmantle pressure) is crucial for understanding CSF circulation and the pathogenesis of certain neurodegenerative diseases. This pressure can be approximated by the pressure difference across the aqueduct (ΔP). Currently, no dedicated platform exists for quantifying ΔP, and no research has been conducted on the impact of breathing on ΔP.
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January 2025
Department of Radiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Objectives: To explore the reproducibility of the 1.5-T MR imaging (MRI)-based R2* method in measuring the liver iron concentration (LIC) across different MRI scanners, scan parameters, and postprocessing techniques.
Materials And Methods: We performed a systematic search of the PubMed, Embase, Medline, Cochrane Library, and Web of Science databases and identified studies that used the 1.
Alzheimers Dement
December 2024
Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Background: In-vivo magnetic resonance imaging (MRI) has recently shown that patients with clinically diagnosed Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) exhibit degeneration of the cholinergic nucleus basalis of Meynert and its white matter (WM) projections through the cingulum and external capsule pathways. Here, we propose an imaging-pathologic validation study aimed at investigating cholinergic WM pathways using post-mortem MRI of autopsy-confirmed AD, Lewy body dementia (LBD), and other neurodegenerative diseases (OTH).
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Alzheimers Dement
December 2024
Illinois Institute of Technology, Chicago, IL, USA.
Background: Intracranial atherosclerosis is a common age-related neuropathology that has been linked to cognitive decline and dementia and often mixed with Alzheimer's and other neuropathologies. But the association of atherosclerosis with brain morphometric abnormalities has not been explored. This work combined Deformation-based morphometry on ex-vivo MRI with detailed neuropathological examination in a large number of community-based older adults to investigate the association.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Illinois Institute of Technology, Chicago, IL, USA.
Background: Brain arteriolosclerosis is characterized by the thickening of vessel walls and arteriolar stenosis and is one of the primary pathologies of cerebral small vessel disease. Arteriolosclerosis is linked to lower cognitive and motor function, as well as an elevated risk of dementia. This study aimed to investigate the association of brain arteriolosclerosis with regional gray matter volumes in a large number of community-based older adults.
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