Human engineering is generally concerned with the design of human tasks, systems, and environments so that people can work and live safely, comfortably, and effectively. As a product of World War II, human engineering has until recently been primarily concerned with military and aerospace systems. Lately, however, the field has been focussing on broader societal problems. Many human engineering principles can easily be generalized to cover the design of certain features of environments for the aged. However, the most effective use of human engineering in this area will require research to supply better information about the aged, their needs, capacities and limitations.
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Wound Healing Splinting Devices for Faster Access and Use.
JID Innov
March 2025
Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA.
With the goal of studying skin wound healing and testing new drug treatments to enhance wound healing in rodent models, there is a clear need for improved splinting techniques to increase surgical efficiency and support routine wound monitoring. Splinted wound healing models humanize wound healing in rodents to prevent contraction and instead heal through granulation tissue deposition, increasing the relevance to human wound healing. Current technologies require suturing and heavy wrapping, leading to splint failure and cumbersome monitoring of the wound.
View Article and Find Full Text PDFEnhanced detection of circulating tumor cells using a MUC1 promoter-driven recombinant adenovirus.
Front Oncol
January 2025
The Pq Laboratory of BiomeDx/Rx, Department of Biomedical Engineering, Binghamton University, Binghamton, NY, United States.
Introduction: Circulating tumor cells (CTCs) have attracted significant interest as a biomarker for cancer diagnosis. In this study, we judiciously constructed a recombinant MUC1-dependent adenovirus (rAdF35-MUC1) that can selectively replicate and overexpress copepod super green fluorescent proteins (copGFP) in MUC1-positive tumor cells to investigate its role in the detection of CTCs.
Methods: We conducted a comparative study between rAdF35-MUC1 and the existing hTERT-dependent adenovirus (rAdF35-hTERT).
Oscillatory fluid flow enhanced mineralization of human dental pulp cells.
Front Bioeng Biotechnol
January 2025
Department of Preventive Dentistry, Division of Pediatric Dentistry, Faculty of Dentistry, Naresuan University, Phitsanulok, Thailand.
The purpose of this study is to evaluate the optimum frequency of oscillatory fluid flow (OFF) for increasing osteogenesis in human dental pulp cells (DPCs) in an incubating rocking shaker. DPCs from 3 donors were cultured in an osteogenic induction medium (OIM) and mechanical stimulation was applied using an incubating rocking shaker at frequencies of 0 (control), 10, 20, 30, and 40 round per minute (RPM) for 1 h/day, 5 days/week. Cell proliferation was measured using total protein quantification, and osteogenic activity was measured by alkaline phosphatase (ALP) activity, calcium deposition, and collagen production on days 7, 14, and 21 of culture.
View Article and Find Full Text PDFHeat source recognition sensor mimicking the thermosensation function of human skin.
Innovation (Camb)
September 2024
Department of Materials Science and Engineering, Southern University and Science and Technology, Shenzhen 518055, China.
The human skin maintains a comfortable and healthy somatosensory state by sensing different aspects of the thermal environment, including temperature value, heat source, energy level, and duration. However, state-of-the-art thermosensors only measure basic temperature values, not the full range of the thermosensation function of human skin. Here, we propose a heat source recognition () sensor of poly(butyl acrylate)-lithium bis(n-fluoroalkylsulfonyl)imide (PBA-Li:FSI; = 1, 3, 5), which enables response to temperature, pressure, and proximity stimulus signals based on the relaxation behavior of the ionic gel and distinguished between different types of heat sources (i.
View Article and Find Full Text PDFA pilot human study using ketamine to treat disorders of consciousness.
iScience
January 2025
Coma Science Group, GIGA-Consciousness, University of Liège, Liège, Belgium.
Post-comatose disorders of consciousness (DoC) represent persistent neurological conditions with limited therapeutic options and a poor prognosis. Recent works advocate for exploring the effects of psychedelics to enhance brain complexity in DoC and ameliorate their consciousness. We investigated sub-anesthetic concentration of the atypical psychedelic ketamine for treating post-comatose prolonged DoC through a double-blind, placebo-controlled, cross-over trial involving three adult patients.
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