AI Article Synopsis
- The male-specific region (MSY) of the Y chromosome is crucial for male sex determination and sperm production, housing many fertility-related genes in ampliconic regions.
- Genetic evolution suggests that some of these Y chromosome genes originated from X-linked or autosomal ancestors, which may enhance male fertility; however, this has only been confirmed for genes DAZ and CDY.
- The study identifies a homologous region on chromosome 8q11.2 that includes multiple genes linked to fertility and highlights a newly discovered gene, BEYLA, along with its genomic structure and expression patterns.
Article Abstract
The male-specific region (MSY) of the Y chromosome contains genes involved mainly in male sex determination and in spermatogenesis. The majority of genes involved in male fertility are localized in multiple copies in the long arm of the Y chromosome, within specific regions defined as "ampliconic regions." It has been suggested that these genes derived from X-linked or autosomal ancestors during evolution, providing a benefit for male fertility when transposed onto the Y chromosome. So far, the autosomal origin has been demonstrated only for two MSY genes, DAZ and CDY. In the present study we report on the identification within chromosome 8q11.2 of a region homologous to the g amplicon, containing the VCY2 (approved gene symbol BPY2), TTTY4, and TTTY17 genes. A search for ancestor genes within the 8q11.2 region allowed us to identify a gene named BEYLA and to characterize the genomic organization and the expression patterns of this gene.
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| http://dx.doi.org/10.1016/j.ygeno.2004.10.015 | DOI Listing |
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