Objective: To determine the clinical and parasitological response to treatment of intestinal microsporidiosis with albendazole.
Design: Open prospective study.
Setting: Hospital-based HIV/genito-urinary medicine unit.
Patients, Participants: Six consecutive AIDS patients with small intestinal microsporidiosis as the only identified cause of diarrhoea after intensive gastrointestinal investigations.
Results: Diarrhoea resolved completely in all patients within 1 week of starting treatment, and body weight stabilized or increased. Four patients who relapsed at 19-31 days after the cessation of treatment responded to a second course of albendazole. Degenerative changes occurred in the parasites after treatment, which had not been seen either in pre-treatment biopsies or, in four patients, following therapy with other drugs.
Conclusions: Albenazole is a useful palliative treatment for microsporidial diarrhoea.
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