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Case report: Rapid recovery after intrathecal rituximab administration in refractory anti-NMDA receptor encephalitis: report of two cases.
Front Immunol
March 2024
Department of Neurology, American University of Beirut Medical Center, Beirut, Lebanon.
Background: Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is one of the most prevalent etiologies of autoimmune encephalitis. Approximately 25% of anti-NMDAR encephalitis cases prove refractory to both first- and second-line treatments, posing a therapeutic dilemma due to the scarcity of evidence-based data for informed decision-making. Intravenous rituximab is commonly administered as a second-line agent; however, the efficacy of its intrathecal administration has rarely been reported.
View Article and Find Full Text PDFThe effect of intrathecal morphine on urinary bladder function after Caesarean delivery: risk-benefit dilemma.
Anaesth Crit Care Pain Med
December 2023
Department of Anaesthesia and Critical Care Medicine, Cairo University, Cairo, Egypt.
Diagnosing Intravascular Large B-Cell Lymphoma: A Tale of Hide and Seek.
Case Rep Oncol
November 2022
Department of Internal Medicine, Banner-University of Arizona Medical Center, Phoenix, Arizona, USA.
We are reporting the first documented case of intravascular large B-cell lymphoma (IVLBCL) manifesting in the endomysial and perimysial capillaries with its associated diagnostic dilemma. Our patient presented with progressive paraplegia. Initial laboratories were remarkable for hyponatremia, hypochloremia, lactic acidosis, elevated C-reactive protein, and lactate dehydrogenase.
View Article and Find Full Text PDFnosocomial meningitis following spinal anesthesia - still a significant treatment dilemma.
Surg Neurol Int
September 2022
Department of Stroke Unit, University Hospital Centre "Mother Teresa", Tirana, Albania.
Background: Infections of central nervous system after spinal anesthesia nowadays are a rarity; however, their presence might be of concern.
Case Description: We report the case of lateral ventricular empyema treated unsuccessfully with parenteral antibiotic therapy, with the clinical signs of a persisting meningitis. After several lumbar taps suggesting an infection, was isolated and a brain magnetic resonance imaging find out the collection in the left horn of the lateral ventricle.
Global Neurocognitive and Frontal Functions Analysis and Precision Intrathecal Pressure Measurement to Settle the Diagnostic Dilemma of the Normal Pressure Hydrocephalus: A Preliminary Experience.
World Neurosurg
November 2022
Neurosurgery Division, A.O. "Santa Maria Goretti" General Hospital, Latina, Italy.
Introduction: Normal-pressure hydrocephalus (NPH) is a common condition associated with a cognitive deterioration and possibly involving up to 9%-14% of all nursing home residents older than 65 years old. The purpose of the present paper is to introduce an inclusive study protocol aimed at increasing the diagnostic precision and follow-up accuracy.
Methods: A total of 28 patients were operated on for NPH in our institution in the period ranging between January 2015 and December 2019.
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