Several experiments have detected that melatonin exerts a marked influence on the inflammatory process. In the present study we evaluated the effect of exogenous melatonin on the experimental granulomatous tissues in rat. Our data show that subcutaneous administration of different doses of melatonin given daily during 6 days at 9:00 h do not have significant action on the granuloma weight. On the other hand melatonin (4 mg/kg) administered at 17:00 h showed a remarkable action pro-inflammatory. However, this effect was abolished when the animals received previously higher doses of melatonin (40 mg/kg) at 9:00 h.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1023/b:ifla.0000049043.89586.89 | DOI Listing |
Publication Analysis
Top Keywords
melatonin experimental
8
experimental granulomatous
8
doses melatonin
8
melatonin mg/kg
8
melatonin
5
effects melatonin
4
granulomatous inflammation
4
inflammation experiments
4
experiments detected
4
detected melatonin
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!