AI Article Synopsis
- The report studies how acute NMDA antagonism affects the expression of RGS2 and the sensitivity of adenylyl cyclase in the rat striatum.
- It finds that the NMDA antagonists MK-801 and phencyclidine lead to a rapid and dose-dependent down-regulation of RGS2 mRNA levels.
- The results indicate a relationship between NMDA receptors and adenylyl cyclase, suggesting that RGS proteins influenced by ionotropic receptors can modify metabotropic receptor signaling.
Article Abstract
The present report examines the effects of acute NMDA antagonism on Regulator of G Protein Signaling 2 (RGS2) expression and adenylyl cyclase sensitivity in the rat striatum. MK-801 and phencyclidine rapidly down-regulate RGS2 mRNA. The down-regulation of RGS2 by MK-801 was dose dependent and transient. Because previous reports showed that RGS2 attenuates activity of adenylyl cyclase, RGS2 protein level and sensitivity of adenylyl cyclase to forskolin was tested 2 h after administration of MK-801 (1 mg/kg). In striatal membranes of these rats, RGS2 protein level was 17% lower and forskolin-stimulated cAMP production 38% higher than in controls. These findings reveal a cross-talk between NMDA receptors and adenylyl cyclase and suggest a general cross-talk mechanism by which RGS proteins transcriptionally regulated by ionotropic receptors can alter signaling properties of metabotropic receptors.
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| http://dx.doi.org/10.1097/00001756-200502080-00018 | DOI Listing |
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