AI Article Synopsis
- Selenium-containing proteins play a crucial role in protecting cells from oxidative damage.
- A study found that depleting selenium led to significant decreases in specific selenoprotein gene expressions in rat colonic mucosa and human Caco-2 cells.
- The results indicate a strong sensitivity of selenoprotein W expression to selenium levels in the colon.
Article Abstract
Selenium (Se)-containing proteins have important roles in protecting cells from oxidative damage. This work investigated the effects of Se-depletion on the expression of the genes encoding selenoproteins in colonic mucosa from rats fed diets of different Se content and in human intestinal Caco-2 cells grown in Se-adequate or Se-depleted culture medium. Se-depletion produced statistically significant (P<0.05) falls in glutathione peroxidase (GPX) 1 mRNA (60-83%) and selenoprotein W mRNA (73%) levels, a small but significant fall in GPX4 mRNA (17-25%) but no significant change in GPX2. The data show that SelW expression in the colon is highly sensitive to Se-depletion.
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| http://dx.doi.org/10.1016/j.febslet.2004.12.042 | DOI Listing |
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