We propose a method for evaluation of spontaneous aggregation of mouse platelets based on routine clinical blood tests for humans. Comparative analysis of Vasaprostan and Alprostan drugs showed that this test can be used for testing of new drugs on animals.
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In 8 patients, operated for postoperative spreaded purulent peritonitis, umbilical vein was catheterized, postoperatively angiographic investigation was performed, leaving catheter in tr. coeliacus or a. mesenterica superior, through which regionary hemodilution, using drop infusion of 20 mcg of alprostan during 3-4 days.
View Article and Find Full Text PDFTotal 50 patients with lower limb intermittent claudication (Fontain-Pokrovsky limb stage of chronic ischemia) due to femoropopliteal or ileofemoral atherosclerotic occlusion were treated with Alprostan (Prostaglandin El) in A.V. Vishnevsky Institute of Surgery, Moscow, from November 2003 to March 2005.
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View Article and Find Full Text PDFComparative study of vasaprostan and alprostan in spontaneous platelet aggregation test in mice.
Bull Exp Biol Med
October 2004
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino.
We propose a method for evaluation of spontaneous aggregation of mouse platelets based on routine clinical blood tests for humans. Comparative analysis of Vasaprostan and Alprostan drugs showed that this test can be used for testing of new drugs on animals.
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