Gnotobiotic piglets inoculated with Escherichia coli O157:H7, its luxS mutant derivative, or nonpathogenic E. coli were evaluated for attaching and effacing lesions. Although no differences in clinical symptoms were seen between pigs inoculated with the parent and those inoculated with the luxS mutant, the luxS mutant-inoculated pigs had a lower frequency of attaching and effacing lesions in the spiral colon than parent strain-inoculated pigs.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC547016 | PMC |
| http://dx.doi.org/10.1128/IAI.73.2.1214-1216.2005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
mutants cause hyperinflammatory responses during chronic infection.
Microbiol Spectr
January 2025
Department of Microbiology and Environmental Toxicology, University of California Santa Cruz, Santa Cruz, California, USA.
Unlabelled: infects roughly half the world's population, causing gastritis, peptic ulcers, and gastric cancer in a subset. These pathologies occur in response to a chronic inflammatory state, but it is not fully understood how controls this process. We characterized the inflammatory response of mutants that cannot produce the quorum sensing molecule autoinducer 2 (AI-2) by deleting the gene for the AI-2 synthase, .
View Article and Find Full Text PDFThe Gene Cluster - Negatively Regulates Biofilm Formation in .
Int J Mol Sci
November 2024
School of Bioscience and Bioengineering, South China University of Technology, Guangzhou 510641, China.
() is a zoonotic foodborne pathogen that is widely distributed worldwide. Its optimal growth environment is microaerophilic conditions (5% O, 10% CO), but it can spread widely in the atmospheric environment. Biofilms are thought to play an important role in this process.
View Article and Find Full Text PDFLuxS/AI-2 system facilitates the dissemination of antibiotic-resistant plasmids in Klebsiella pneumoniae.
Int J Antimicrob Agents
December 2024
Department of Clinical Laboratory Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200082, People's Republic of China; Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China. Electronic address:
Plasmid conjugation is a central mechanism driving the dissemination of antibiotic resistance in Klebsiella pneumoniae. However, the conjugative operon requires specific stimuli for activation. Identifying signals and elucidating the underlying mechanisms is crucial in combating plasmid spread.
View Article and Find Full Text PDFEffects of AI-2 quorum sensing related luxS gene on Streptococcus suis formatting monosaccharide metabolism-dependent biofilm.
Arch Microbiol
September 2024
College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, 471000, China.
Biofilm is the primary cause of persistent infections caused by Streptococcus suis (S. suis). Metabolism and AI-2 quorum sensing are intricately linked to S.
View Article and Find Full Text PDFThe absence of reduces the invasion of but is not essential for virulence.
Front Vet Sci
August 2024
Beijing Key Laboratory for Prevention and Control of Infectious Diseases in Livestock and Poultry, Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, Beijing, China.
Article Synopsis
- The research investigates the role of the LuxS/AI-2 quorum-sensing system in a respiratory pathogen affecting poultry, specifically focusing on a certain gene's function.
- Findings reveal that the deletion of this gene impairs the pathogen's ability to invade host cells, but does not significantly alter its overall pathogenicity in chickens.
- Despite the reduced invasion capability, both the mutant and wild-type strains caused infections in chickens, with only minor differences in symptoms observed.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!