1-Hydroxyalkyl-3-phenylthioureas as novel HDL-elevating agents.

Bioorg Med Chem Lett

Department of Diabetes and Metabolism, Novartis Institutes for Biomedical Research, 100 Technology Square, Cambridge, MA 02139, USA.

Published: February 2005

A series of 1-hydroxyalkyl-3-phenylthiourea analogs were prepared and evaluated as HDL-and Apo A-I-elevating agents. Derivatives 5h, 7j, 7n, and 7o were found to be as effective or superior to gemfibrozil.

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http://dx.doi.org/10.1016/j.bmcl.2004.10.094DOI Listing

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