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Benzimidazole derivatives as novel nonpeptide luteinizing hormone-releasing hormone (LHRH) antagonists. Part 1: Benzimidazole-5-sulfonamides. | LitMetric
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Benzimidazole derivatives as novel nonpeptide luteinizing hormone-releasing hormone (LHRH) antagonists. Part 1: Benzimidazole-5-sulfonamides.

Kentaro Hashimoto Miyuki Tatsuta Mikayo Kataoka Kayo Yasoshima Yuka Shogase Makoto Shimazaki Takeshi Yura Yingfu Li Noriyuki Yamamoto Jang B Gupta Klaus Urbahns

Bioorg Med Chem Lett

Department of Chemistry, Research Center Kyoto, Bayer Yakuhin, Ltd, Kizu, Soraku, Kyoto 619-0216, Japan.

Published: February 2005

A new class of benzimidazole-5-sulfonamides has been identified as nonpeptide luteinizing hormone-releasing hormone (LHRH) antagonists. Initial structure-activity relationships are presented resulting in compounds 19 and 28 with submicromolar dual functional activity on human and rat receptors.

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http://dx.doi.org/10.1016/j.bmcl.2004.10.089DOI Listing

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