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Efficacy of Letrozole vs Clomiphene Citrate for induction of ovulation in women with polycystic ovarian syndrome.
Pak J Med Sci
January 2024
Sonia Irshad, FCPS-I, Department of Obstetrics and Gynaecology, Services Hospital Lahore, Lahore, Pakistan.
Objective: To compare the efficacy of letrozole vs Clomiphene citrate for ovulation induction in PCOS women.
Methods: This double blind randomized controlled trial was conducted at Services Hospital, Lahore, from January 2016 to December 2020. Total 220 patients, diagnosed with PCOS according to Rotterdam criteria were randomly assigned into two groups after taking informed consent.
Comparison of Letrozole and Clomiphene Citrate in Pregnancy Outcomes in Patients with Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis.
Reprod Sci
April 2024
Department of Obstetrics and Gynecology, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia.
Article Synopsis
- * The review included 50 randomized clinical trials and found that letrozole significantly improved endometrial thickness, ovulation rates, and pregnancy rates compared to CC, although CC resulted in more follicles.
- * The findings suggest that letrozole could be a better first-line treatment for chronic anovulation in PCOS patients, but larger studies are needed for confirmation.
Follicular homocysteine as a marker of oocyte quality in PCOS and the role of micronutrients.
J Assist Reprod Genet
August 2023
Parthenogen, R&D Department, Lugano, Switzerland.
Purpose: Does follicular homocysteine predict the reproductive potential of oocytes following FSH stimulation in PCOS women? Can it be modulated by dietary interventions?
Methods: This was a prospective, randomized, interventional clinical study. Forty-eight PCOS women undergoing in vitro fertilization at a private fertility clinic were randomized for a dietary supplementation providing micronutrients involved in homocysteine clearance or no treatment. The supplement was assumed 2 months before stimulation until pick-up day.
The importance of follicular flushing in optimizing oocyte retrieval.
Curr Opin Obstet Gynecol
June 2023
Unit of Human Reproduction, First Department of OB/Gyn, Medical School, Aristotle University, Thessaloniki, Greece.
Purpose Of Review: To critically evaluate the use of follicular flushing during oocyte retrieval.
Recent Findings: The latest meta-analysis evaluating follicular flushing does not favour its use over single aspiration. The randomized controlled trials (RCTs) included, however, are characterized by significant heterogeneity regarding the population analysed, the needle type and lumen used, the aspiration pressure applied and the number of flushing attempts performed.
Does follicular flushing increase oocyte number in poor responders? An update of a systematic review.
Reprod Biomed Online
February 2023
Department of Gynaecological Endocrinology and Reproductive Medicine, University Hospital of Schleswig-Holstein, Campus Luebeck, Luebeck, Germany.
Research Question: Does flushing of the follicles at ovum retrieval increase the number of retrieved oocytes in poor-response IVF patients?
Design: An update of an electronic literature search was performed to identify randomized controlled trials (RCT) investigating follicular flushing versus no flushing in women with a poor response to IVF treatment. No exclusion criteria for type of needle, stimulation or protocol were applied. A meta-analysis was conducted using the software RevMan 5.
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