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Candida auris is an emerging, multidrug-resistant fungus that poses a threat in health care settings because of its persistence on surfaces and ability to cause severe infections, particularly in immunocompromised patients. First identified in Japan in 2009, C auris has since spread globally, leading to numerous outbreaks. Its unique virulence factors, such as biofilm formation and immune evasion, contribute to its resilience and resistance to eradication.

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From pain to meningitis: bacteria hijack nociceptors to promote meningitis.

Front Immunol

January 2025

National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, Guangdong, China.

Bacterial meningitis is a severe and life-threatening infection of the central nervous system (CNS), primarily caused by and . This condition carries a high risk of mortality and severe neurological sequelae, such as cognitive impairment and epilepsy. Pain, a central feature of meningitis, results from the activation of nociceptor sensory neurons by inflammatory mediators or bacterial toxins.

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Risk Factors and Outcomes of Invasive Candida Infections in Heart Transplant Recipients: A Case-Control Study.

Clin Transplant

February 2025

Division of Geographic Medicine and Infectious Diseases, Department of Medicine, Tufts Medical Center, Boston, Massachusetts, USA.

Background: Invasive Candida infections (ICI) are the most common invasive fungal infections in solid organ transplant recipients. There are limited contemporary data on the risk factors for infection in heart transplant (HT) recipients especially since the expansion of temporary mechanical circulatory support (MCS) use.

Methods: This was a case-control study conducted at a tertiary care academic hospital of HT recipients from January 2022 to January 2024.

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Background: Carbapenem-resistant Gram-negative bacteria and methicillin-resistant Staphylococcus aureus (MRSA) are among WHO's priority pathogens with antimicrobial resistance (AMR). Studies suggest potential impacts of the COVID-19-pandemic on AMR. We described changes in AMR incidence and epidemiology in Germany during the COVID-19-pandemic.

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Epidemiology of invasive Haemophilus influenzae infections in Belgium: 2018-2022.

Eur J Clin Microbiol Infect Dis

January 2025

National reference centre for Haemophilus influenzae, Department of microbiology, Laboratoire Hospitalier Universitaire de Bruxelles - Universitair Laboratorium Brussel (LHUB-ULB), Université libre de Bruxelles, Brussels, Belgium.

Introduction: Haemophilus influenzae plays a major role in invasive bacterial infections. Resistant strains are emerging, prompting the WHO to include H. influenzae on its list of priority pathogens for research and development of new antibiotics.

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