Adverse reactions to human rabies immune globulin manufactured by the Thai Red Cross Society.

Vaccine

Queen Saovabha Memorial Institute, Thai Red Cross Society (WHO Collaborating Center for Research in Rabies) and Department of Medicine, Chulalongkorn University, 1871 Rama IV Road, 10330 Bangkok, Thailand.

Published: February 2005

AI Article Synopsis

  • Rabies Immunoglobulins (RIG) are crucial for managing rabies exposures, offering immediate protection until the body's immune response kicks in after vaccination.
  • Even though Human Rabies Immune Globulin (HRIG) is the preferred treatment, it can cause rare side effects similar to other biological products.
  • A study involving 8,737 patients found that only 0.183% experienced mild, temporary adverse reactions after receiving HRIG.

Article Abstract

Rabies Immunoglobulins (RIG) are an essential part of optimal management of rabies exposures [World Health Organization (WHO)]. They provide protection against the virus during the critical initial 7 days before adequate endogenous vaccine induced antibodies are formed. Even though Human Rabies Immune Globulin (HRIG) is the ideal product for post-exposure rabies treatment it, like most biological, can cause very rare adverse reactions. A retrospective review of a series of 8737 patients, who received HRIG at one institution, revealed that only 15 (0.183 %) reported transient mild adverse reactions.

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Source
http://dx.doi.org/10.1016/j.vaccine.2004.09.013DOI Listing

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