The growing importance of fat in regenerative medicine.

Trends Biotechnol

Macropore Biosurgery Inc., 6740 Top Gun Street, San Diego, California 92121, USA.

Published: February 2005

A recent publication by Michael Longaker and colleagues represents a landmark for the use of adipose tissue as a source of cells for tissue regeneration. The authors investigated the ability of adipose tissue-derived cells (ADCs) to regenerate critical size calvarial (superior portion of the skull) defects in mice by using a novel osteoconducive apatite-coated Poly-lactic-co-glycolic acid (PLGA) scaffold for cell delivery. Direct comparison of this osteogenic ability was performed with bone marrow stromal cells and juvenile calvarial-derived osteoblasts.

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http://dx.doi.org/10.1016/j.tibtech.2004.12.003DOI Listing

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