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Efficacy and safety of non-pharmacological, pharmacological and surgical treatments for hand osteoarthritis in 2024: a systematic review.
RMD Open
January 2025
Health Services Research and Innovation Unit, Diakonhjemmet Hospital, Oslo, Norway.
Background: We aimed to update the 2018 systematic literature review on the efficacy and safety of treatments for hand osteoarthritis (OA), which was based on 126 studies.
Methods: We performed a systematic literature search on randomised controlled trials from June 2017 up to 31 December 2023. Risk of bias was assessed using the RoB2 tool.
Cytokine release syndrome caused by immune checkpoint inhibitors: a case report and literature review.
Future Sci OA
December 2024
Department of Medical Oncology, Zhongshan Hospital, Fudan University, Shanghai, China.
Immune checkpoint inhibitors (ICIs) have gained widespread application in the treatment of malignant tumors. Cytokine release syndrome (CRS) is a systemic inflammatory response triggered by various factors, including infections and immunotherapy. We present a case of CRS occurring in a gastric cancer patient after receiving combination therapy of tislelizumab, anlotinib and combination of capecitabine and oxaliplatin.
View Article and Find Full Text PDFAquo-ethanolic extract of Lilii Bulbus attenuates dexamethasone-induced muscle loss and enhances muscle strength in experimental mice.
Biomed Pharmacother
December 2024
KM Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea. Electronic address:
Traditionally, Lilium lancifolium bulb is known for its ability to nourish yin, nourish the lungs, clear the heart, soothe coughs, reduce irritability, and calm the mind. In Oriental Medicine, it is categorized as a tonic remedy for alleviating symptoms of fatigue and enhancing the strength of bones and muscles. In this study, we aimed to validate the effectiveness of the aquo-ethanolic extract of Lilli Bulbus (LBE) in a dexamethasone (DEX)-induced muscle atrophy model, both in vitro and in vivo, and elucidate its mechanism of action through muscle transcriptome analysis.
View Article and Find Full Text PDFGenetic testing for familial hyperaldosteronism type 1 in Aotearoa/New Zealand.
Intern Med J
November 2024
Endocrinology Unit, Te Whatu Ora Waikato, Hamilton, New Zealand.
Article Synopsis
- Primary aldosteronism (PA) is a significant cause of hypertension, and familial hyperaldosteronism type 1 (FH-1) is a hereditary form that can lead to severe health issues, making early detection important.
- A study analyzed genetic testing data for FH-1 in New Zealand from April 2010 to October 2023, revealing that only 147 tests were conducted, with a positive result in 12.9% of cases and significant variations in testing rates by region.
- Although testing rates for FH-1 have increased over the years, they are still considered low, indicating a need for more awareness and testing, especially for individuals diagnosed with PA at a young age or those with a family
[Pulsed thulium laser combined with pulsed thulium laser injection for the treatment of failed urethral anastomosis].
Zhonghua Nan Ke Xue
May 2024
Department of Urology and Andrology, Gongli Hospital of Shanghai Pudong New Area, Shanghai 200135, China.
Article Synopsis
- - The study aimed to evaluate the effectiveness of pulsed thulium laser (PTL) combined with triamcinolone injections for treating failed posterior urethral anastomosis (FPUA) in 35 male patients.
- - Patients underwent either PTL or plasma treatment along with the steroid injection and were monitored for changes in urinary flow and complications over an average follow-up of 21 months.
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