AI Article Synopsis
- The study investigates how flavone extracted from Diospyros kaki leaves affects the growth of rat vascular smooth muscle cells (VSMCs) stimulated by low-density lipoprotein (LDL).
- The research involved growing VSMCs in a lab and testing them with LDL and flavone, with the effects measured against a control group.
- Results showed that flavone significantly reduced the proliferation of VSMCs in the presence of LDL, suggesting it could have protective effects on blood vessels in conditions of high cholesterol.
Article Abstract
Objective: To observe whether rat vascular smooth muscle cells (VSMCs) proliferation induced by native low-density lipoprotein (LDL) is affected by flavone from leaves of Diospyros kaki in vitro.
Methods: Rat aortic VSMCs were cultured in vitro and treated with LDL and flavone from leaves of Diospyros kaki, respectively, and were observed in comparison with the control group. The ratio of cell proliferation was determined by non-radioactive MTS/PES assay.
Results: Compared with control, flavone from leaves of Diospyros kaki can dose-dependently inhibit LDL-stimulated vascular smooth muscle cells proliferation (P < 0.05).
Conclusions: The flavone from leaves of Diospyros kaki can inhibit proliferation of rat vascular smooth muscle cells exposed to high levels of native LDL. Flavone from leaves of Diospyros kaki may exert vascular protection by inhibiting vascular smooth muscle cell growth associated with hypercholesterolemia.
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