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Mitigation of polystyrene microplastic-induced hepatotoxicity in human hepatobiliary organoids through bile extraction.
Ecotoxicol Environ Saf
December 2024
Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8102, Japan. Electronic address:
Background & Aims: Polystyrene microplastics (PS-MPs) are pervasive in our daily life and can be ingested by the human body through bioaccumulation, causing organ damage, especially liver damage. However, the effect of PS-MPs bioaccumulation on human hepatotoxicity and their metabolism remains unclear. Recent studies have demonstrated that PS-MPs cause lipid and bile acid metabolism disorders.
View Article and Find Full Text PDFPotential involvement of PPARs in the inhibition of mammary lipid synthesis during diet-induced milk fat depression.
J Dairy Sci
November 2024
Department of Animal Science, Penn State University, University Park, 16802; Department of Animal Science, Cornell University, Ithaca, NY 14850. Electronic address:
The objective of this study was to evaluate the possible role of the peroxisome proliferator-activated receptors (PPARs: PPAR-α, PPAR-β/δ, and PPAR-γ) in diet and conjugated linoleic acid (CLA)-induced milk fat depression (MFD) in dairy cows. We hypothesized that the expression of PPARs, which regulate lipid metabolism and bind to polyunsaturated fatty acids, could be modulated by biohydrogenation intermediates that induce MFD, thereby interfering with milk fat synthesis. First, tissue profiling revealed that PPAR-α and PPAR-β/δ had low expression in mammary tissue compared with the liver.
View Article and Find Full Text PDFExploration of the link between COVID-19 and gastric cancer from the perspective of bioinformatics and systems biology.
Front Med (Lausanne)
September 2024
Division of Liver Surgery, Department of General Surgery and Laboratory of Liver Surgery, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Background: Coronavirus disease 2019 (COVID-19), an infectious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has caused a global pandemic. Gastric cancer (GC) poses a great threat to people's health, which is a high-risk factor for COVID-19. Previous studies have found some associations between GC and COVID-19, whereas the underlying molecular mechanisms are not well understood.
View Article and Find Full Text PDFProtocol to create phenotypic primary human hepatocyte cultures using the RASTRUM 3D cell model platform.
STAR Protoc
September 2024
Inventia Life Science, Alexandria, NSW 2015, Australia. Electronic address:
To improve human hepatotoxicity prediction, in vitro liver cell models replicating hepatocyte function, drug metabolism, and toxicity are required. Here, we present a protocol for creating 3D primary human hepatocyte (PHH) cell models using the RASTRUM Platform. We describe the process for PHH model generation; procedures for characterizing the PHH model, including viability, albumin production, and CYP450 inducibility; and drug treatment using acetaminophen and troglitazone.
View Article and Find Full Text PDFUncovering the mechanism of troglitazone-mediated idiosyncratic drug-induced liver injury with individual-centric models.
Arch Toxicol
November 2024
PredictCan Biotechnologies SAS, Biopôle Euromédecine, 1682 Rue de La Valsière, 34790, Grabels, France.
Idiosyncratic drug-induced liver injury is a rare and unpredictable event. Deciphering its initiating-mechanism is a hard task as its occurrence is individual dependent. Thus, studies that utilize models that are not individual-centric might drive to a general mechanistic conclusion that is not necessarily true.
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