Variability in fMRI: a re-examination of inter-session differences.

Hum Brain Mapp

Oxford Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB), Department of Clinical Neurology, Oxford University, John Radcliffe Hospital, Headington, Oxford, United Kingdom.

Published: March 2005

We revisit a previous study on inter-session variability (McGonigle et al. [2000]: Neuroimage 11:708-734), showing that contrary to one popular interpretation of the original article, inter-session variability is not necessarily high. We also highlight how evaluating variability based on thresholded single-session images alone can be misleading. Finally, we show that the use of different first-level preprocessing, time-series statistics, and registration analysis methodologies can give significantly different inter-session analysis results.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6871748PMC
http://dx.doi.org/10.1002/hbm.20080DOI Listing

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