The study was designed to compare the information priorities of Italian early-stage prostate cancer patients to those of their health-care professionals. Doctors (urologists and oncologists), nurses, radiation therapy technologist (RTs), and patients treated with radiotherapy in Northern Italy were surveyed. Respondents rated the importance of addressing each of 78 questions as: essential, important, or superfluous. We compared priorities between pairs of groups by correlating the percentage of each group that rated each question (a) essential and (b) superfluous. We assessed within-group agreement by identifying questions that >50% of one response. Fifty-nine doctors, 53 nurses, and 45 RTs (overall 70% response rate) and 50 patients (91% response rate) participated. All correlations between professional groups were high (all >0.74). All professional group-patient correlations were significant but much lower than those among the professionals. More importantly, there was considerable variation within each group: within each group, almost all questions were rated essential by some members but less than seven of the 78 questions were rated so by half (or more) of its members. In addition, almost all questions were also rated superfluous by some members of each profession. We concluded that the professional groups appear to agree with one another on questions essential and those superfluous to address more than they agree with a group of their patients. More importantly, there is considerable disagreement within each group. The results imply that the professionals cannot assume that their own information priorities are the same as those of their patients.
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http://dx.doi.org/10.1016/j.pec.2004.02.006 | DOI Listing |
FEBS Open Bio
December 2024
School of Medicine, University of Split, Croatia.
Mitophagy, a selective clearance of damaged or superfluous mitochondria via autophagy machinery and lysosomal degradation, is an evolutionarily conserved process essential for various physiological functions, including cellular differentiation and immune responses. Defects in mitophagy are implicated in numerous human diseases, such as neurodegenerative disorders, cancer, and metabolic conditions. Despite significant advancements in mitophagy research over recent decades, novel and robust methodologies are necessary to elucidate its molecular mechanisms comprehensively.
View Article and Find Full Text PDFmBio
December 2024
Division of Molecular Microbiology and Immunology, CSIR-Central Drug Research Institute, Lucknow, India.
parasites have a complex life cycle that transitions between mosquito and mammalian hosts, and undergo continuous cellular remodeling to adapt to various drastic environments. Following hepatocyte invasion, the parasite discards superfluous organelles for intracellular replication, and the remnant organelles undergo extensive branching and mature into hepatic merozoites. Autophagy is a ubiquitous eukaryotic process that permits the recycling of intracellular components.
View Article and Find Full Text PDFBiochem Soc Trans
October 2024
Membrane Biochemistry and Transport, Institut Pasteur, Université de Paris, UMR3691 CNRS, 75015 Paris, France.
Sensors (Basel)
September 2024
Computer Science Department, Faculty of Computers and Information, Menoufia University, Shebin Elkom 32511, Egypt.
Adv Sci (Weinh)
October 2024
Department of Physiology, Institute of Brain and Intelligence, Third Military Medical University, Chongqing, 400038, China.
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