Objective: To evaluate sperm membrane system integrity in unexplained infertile male subjects with three consecutive conception failures on IUI even though semen clinical parameters were normal.
Design: Prospective study.
Setting: Medical biotechnology laboratory, School of Medical Science and Technology IIT Kharagpur, India.
Patient(s): Twenty-nine patients with unexplained infertility, 17 normal proven-fertile healthy donors, and 21 infertile males with low motility but with other semen parameters remaining normal.
Intervention(s): Semen samples were collected from unexplained infertile patients as well as from healthy fertile donors after abstinence of 3-5 days and were analyzed according to World Health Organization guidelines.
Main Outcome Measure(s): Release of 5'-nucleotidase (plasma membrane marker), lactate dehydrogenase (mitochondrial marker) and free acrosin, proacrosin, and total acrosin (acrosomal membrane marker).
Result(s): Plasma membrane integrity and respiratory activity of sperm cells were comparable in all three groups. The proacrosin-acrosin system was adversely affected in unexplained infertile subjects despite high sperm motility.
Conclusion(s): Total acrosin activity may be considered as a sensitive biochemical marker for clinical evaluation of unexplained infertility in males.
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