This paper reviews the pharmacological properties of Mediterranean-grown citrus species (Citrus L., Rutaceae), including citron (Citrus medica L.), lime (Citrus xauantiifolia [Christm.] Swingle), lemon (Citrus xlimon [L.] Osbeck), bitter orange (Citrus xaurantium L.) and pomelo (Citrus maxima [Burm.] Merr.), as referred to in ancient, medieval and 16th century sources. The virtues of the species reported in these texts were compared to those known to modern science. A much broader spectrum of pharmacological properties was recorded by these early writers than one might expect. The use of the citron and lemon as antidotes for 'poison and venom' is recorded in the very earliest material. According to modern scientific literature the citron and the bitter orange may possess anti-cancer activity, lime may have an immunomodulatory effect in humans, and the pomelo may be useful for treating circulatory problems. Lemons might even ease hangover symptoms. Research is required to confirm these properties.
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http://dx.doi.org/10.1016/j.jep.2004.10.019 | DOI Listing |
Mol Pharm
January 2025
Department of Pharmaceutics, School of Pharmacy, Virginia Commonwealth University, Richmond, Virginia 23298, United States.
Chemotherapy-induced peripheral neuropathy (CIPN) is a serious side effect of anticancer agents with limited effective preventive or therapeutic interventions. Although fenofibrate, a peroxisome proliferator-activated receptor-alpha (PPARα) agonist, has demonstrated neuroprotective and analgesic properties, its clinical utility is hindered by low receptor affinity, poor subtype selectivity, and suboptimal bioavailability. A190, a highly selective and potent nonfibrate PPARα agonist, offers a promising alternative but is limited by poor aqueous solubility, resulting in reduced oral bioavailability and therapeutic efficacy.
View Article and Find Full Text PDFPLoS One
January 2025
Department of Dyes and Chemical Engineering, Bangladesh University of Textiles, Dhaka, Bangladesh.
Tinospora cordifolia extract exhibits diverse benefits-anti-arthritis, anti-malarial, anti-allergic, anti-diabetic, antihepatotoxic, and antipyretic effects. Its specific anti-inflammatory and healing capacities remain unexplored, prompting a study utilizing a mouse skin wound model and direct T. cordifolia extraction.
View Article and Find Full Text PDFAppl Microbiol Biotechnol
January 2025
School of Environmental and Life Sciences, The University of Newcastle, Callaghan, NSW, 2308, Australia.
The rapid advancement of nanotechnology, particularly in the realm of pharmaceutical sciences, has significantly transformed the potential for treating life-threatening diseases. A pivotal aspect of this evolution is the emergence of "green nanotechnology," which emphasizes the environmentally sustainable synthesis of raw materials through biological processes. This review focuses on the biological synthesis and application of zinc oxide (ZnO) nanoparticles (NPs) from probiotic bacteria, particularly those sourced from wastewater.
View Article and Find Full Text PDFFASEB J
January 2025
Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
Nonunion is a significant complication in fracture management for surgeons. Salvianolic acid A (SAA), derived from the traditional Chinese plant Salviae miltiorrhizae Bunge (Danshen), exhibits notable anti-inflammatory and antioxidant properties. Although studies have demonstrated its ability to promote osteogenic differentiation, the exact mechanism of action remains unclear.
View Article and Find Full Text PDF<b>Background and Objective:</b> <i>Oroxylum indicum</i>, a plant commonly used in traditional medicine to address various human ailments, has recently gained attention as a promising candidate in this regard due to its rich phytochemical composition and potential antibacterial properties. This study was undertaken to evaluate the antibacterial efficacy of <i>O. indicum</i> extracts, specifically from its leaves and stems, against antibiotic-resistant bacteria.
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