AD7c-NTP, the only known protein entirely encoded by tandem and nested cassettes of Alu repetitive elements, is reportedly over-expressed in brains of Alzheimer's disease patients [de la Monte et al., J. Clin. Invest. 15 (1997)]. Based on these findings a commercial diagnostic assay ("7c Gold"/"AlzheimAlert" ) has been developed. We analyzed the published cDNA sequence and compared it to corresponding EST clones as well as the genomic sequences of human and chimpanzee. We come to the conclusion that the existence of the gene and in particular the predicted protein is inconsistent with EST and genomic data. Previously published data need to be reassessed.
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Does the AD7c-NTP locus encode a protein?
Biochim Biophys Acta
January 2005
Institute of Experimental Pathology, ZMBE, University of Münster, Von-Esmarch-Str. 56, Münster, Germany.
AD7c-NTP, the only known protein entirely encoded by tandem and nested cassettes of Alu repetitive elements, is reportedly over-expressed in brains of Alzheimer's disease patients [de la Monte et al., J. Clin.
View Article and Find Full Text PDFA gene for nonsyndromic mental retardation maps to chromosome 3p25-pter.
Neurology
August 2000
Laboratory of Clinical Neurogenetics, Wadsworth Center, New York State Department of Health, Albany 12201-0509, USA.
Objective: To establish genetic linkage between polymorphic microsatellite loci and a disease locus responsible for an autosomal recessive type of nonsyndromic mental retardation (MR).
Background: Although MR is the most common developmental disability in the United States, the etiologies of most nonsyndromic cases are not known.
Methods: A genealogic database provided information to reconstruct the relationships between 32 individuals from five nuclear families in a single pedigree with 10 affected individuals with nonsyndromic MR.
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