AI Article Synopsis
- PKC delta (deltaPKC) might be involved in the progression of amyotrophic lateral sclerosis (ALS) through its role in mitochondrial apoptosis.
- The study aimed to examine deltaPKC activation in the spinal cord of Wobbler mice, a model for motor neuron disease, and found that deltaPKC levels were significantly lower with increased cleavage present.
- The activation of caspase-3 was observed in motor neurons, suggesting that this enzyme might cleave deltaPKC, leading to disruptions in signaling pathways that could contribute to the disease in Wobbler mice.
Article Abstract
Protein kinase C (PKC) was suggested to play a role in the pathology of amyotrophic lateral sclerosis (ALS) patients. Activation of PKC delta (deltaPKC) modulates mitochondrially induced apoptosis. The goal of the present study was to define whether deltaPKC activation occurs in Wobbler mouse spinal cord (a model of motor neuron disease). The level of deltaPKC in the soluble fraction was significantly decreased in the spinal cord of Wobbler mice, which was associated with a significant increase in deltaPKC cleavage. Since caspase-3 is known to cleave deltaPKC, we determined caspase-3 activation in the Wobbler mice spinal cord, immunohistochemically. The results demonstrated intense immunoreactivity for activated caspase-3 in corticospinal tract motor neurons of Wobbler mice spinal cord. We hypothesize from these results that caspase-3 activation cleaves deltaPKC, which in turn promotes an aberrant signal transduction pathway in the Wobbler spinal cord.
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| http://dx.doi.org/10.1016/j.nbd.2004.08.017 | DOI Listing |
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