AI Article Synopsis
- Soluble Abeta oligomers are implicated in cognitive decline before the formation of senile plaques in Alzheimer's disease (AD).
- A study used immunoelectron microscopy to analyze the presence of these oligomers in the brains of both AD patients and nondemented individuals.
- Results showed a higher density of oligomers in AD brains, particularly around synapses, suggesting their role in synaptic dysfunction related to the disease.
Article Abstract
Soluble Abeta oligomers have recently been considered to be responsible for cognitive dysfunction prior to senile plaque (SP) formation in Alzheimer's disease (AD) brain. To investigate the ultrastructural localization of soluble Abeta oligomers, we conducted the post-embedding immunoelectron microscopic (IEM) study using an antibody against a molecular mimic of oligomeric Abeta. We examined autopsied brains from AD patients and nondemented subjects. Oligomer-specific immunoreactions detected by IEM tended to be found with higher density (1) in AD than in nondemented brains and (2) at the axon and axon terminal in AD than in nondemented brains. These findings imply that soluble Abeta oligomers might be related to synaptic dysfunction in AD brain.
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| http://dx.doi.org/10.1016/j.brainres.2004.10.041 | DOI Listing |
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