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Protective efficacy of classical vaccines and vaccination protocols against an exotic Newcastle disease virus genotype VII.2 in Belgian layer and broiler chickens.
Poult Sci
November 2024
Avian Virology and Immunology, Sciensano, Rue Groeselenberg 99, Uccle, Brussels 1180, Belgium.
Vaccination against Newcastle disease (ND) has been routinely implemented in the Belgian professional poultry sector since 1993, using genotype I and II vaccines. Despite this, an outbreak of genotype VII.2 avian paramyx-ovirus 1 (APMV-1) occurred in 2018, with 20 reported cases over the course of 3 months.
View Article and Find Full Text PDFCharacterizing Host microRNA: Virus Interactions of .
Viruses
November 2024
Exotic and Emerging Avian Viral Disease Research Unit, Southeast Poultry Research Laboratory, US National Poultry Research Center, 934 College Station Road, Athens, GA 30605, USA.
Post-transcriptional gene regulation mediated by microRNAs (miRNAs) relies on sequence complementarity between the miRNA seed site and the target gene transcript(s). This complementarity can completely inhibit or reduce translation into protein. We hypothesized that viruses employ sequence complementarity/similarity with host miRNAs to inhibit or increase the miRNA-mediated regulation of host gene expression specifically during viral infection(s).
View Article and Find Full Text PDFPredicting Bubble Fragmentation in Superfluids.
Phys Rev Lett
August 2024
Joint Quantum Centre (JQC) Durham-Newcastle, School of Mathematics, Statistics and Physics, Newcastle University, Newcastle upon Tyne, NE1 7RU, United Kingdom.
In classical fluids, the Weber number is a dimensionless parameter that characterizes the flow of a multiphase fluid. The superfluid analogy of a classical multiphase fluid can be realized in a system of two or more immiscible Bose-Einstein condensates. These superfluid mixtures have been shown to display a wider variety of exotic dynamics than their single component counterparts.
View Article and Find Full Text PDFDetection and differentiation of low virulence and virulent Orthoavulavirus javaense using a molecular beacon with RT-LAMP.
Sci Rep
August 2024
Exotic and Emerging Avian Viral Disease Research Unit, Southeast Poultry Research Laboratories, US National Poultry Research Center, 934 College Station Road, Athens, GA, 30605, USA.
Newcastle disease (ND), an economically important disease in poultry, is caused by virulent strains of the genetically diverse Orthoavulavirus javaense (OAVJ). Laboratories rely on quantitative real-time reverse transcription PCR (qRT-PCR) to detect OAVJ and differentiate between OAVJ pathotypes. This study demonstrates that a fusion cleavage site based molecular beacon with reverse transcription loop mediated isothermal amplification (MB-RT-LAMP) assay can detect and differentiate OAVJ pathotypes in a single assay.
View Article and Find Full Text PDFMechanochemical Synthesis of a Sodium Anion Complex [Na(2,2,2-cryptand)Na] and Studies of Its Reactivity: Two-Electron and One-Electron Reductions.
Inorg Chem
August 2024
School of Chemistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
Group 1 metal molecular chemistry is dominated by a +1 oxidation state, while a 0 oxidation state is widespread in the metals. A more exotic, yet still available, oxidation state of group 1 metal is -1, i.e.
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