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Global alignment and local curvature of microtubules in mouse fibroblasts are robust against perturbations of vimentin and actin.
Soft Matter
January 2025
Institute for X-Ray Physics, University of Göttingen, Friedrich-Hund-Platz 1, 37077 Göttingen, Germany.
The eukaryotic cytoskeleton is an intricate network of three types of mechanically distinct biopolymers - actin filaments, microtubules and intermediate filaments (IFs). These filamentous networks determine essential cellular functions and properties. Among them, microtubules are important for intracellular transport and establishing cell polarity during migration.
View Article and Find Full Text PDFNucleocapsid assembly drives Ebola viral factory maturation and dispersion.
Cell
December 2024
Schaller Research Groups, Department of Infectious Diseases, Virology, Heidelberg University, Heidelberg, Germany; BioQuant, Heidelberg University, Heidelberg, Germany. Electronic address:
Article Synopsis
- Viral factories (VFs) are membrane-less organelles where negative-sense RNA viruses, like Ebola, replicate and encapsidate their genomes.
- Using advanced imaging techniques, researchers observed how viral nucleocapsids (NCs) change from loose formations to compact structures during the infection process.
- The study found that as VFs mature, they become less spherical and more integrated with cellular components, which likely aids in the transportation of NCs for virus budding.
Cellular distribution of some intermediate filaments in the rat mammary gland during pregnancy, lactation and involution.
Pol J Vet Sci
December 2024
Department of Histology and Embryology, Faculty of Veterinary Medicine, University of Dicle, 21280 Diyarbakır, Turkey.
Intermediate filaments (IFs) play a major role in determining and maintaining cell shape and anchoring intracellular organelles in place, in the tissues and organs of several species, starting from the early stages of development. This study was aimed at the immunohistochemical investigation of the presence, cellular localization and temporal distribution of the intermediate filaments keratin 8 (CK8), keratin 18 (CK18), keratin 19 (CK19), vimentin, desmin and laminin, all of which contribute to the formation of the cytoskeleton in the rat mammary gland during pregnancy, lactation and involution. On days 7, 14 and 21 of pregnancy (pregnancy period), on day 7 post-delivery (lactation period) and on day 7 post-weaning (involution period), under ketamine hydrochloride (Ketalar-Pfizer) (90 mg/kg) anesthesia, two mammary glands were fully excised from the abdominal region.
View Article and Find Full Text PDFTriplet Energy Migration in Cytoskeletal Polymers.
J Phys Chem B
December 2024
Centre for Biomedical Engineering, Indian Institute of Technology, Delhi 110016, India.
Dexter energy transfer (DET) of triplet electronic states is used to direct energy in photovoltaics, quench reactive singlet oxygen species in biological systems, and generate them in photodynamic therapy. However, the extent to which repeated DET between aromatic residues can lead to triplet energy migration in proteins has not been investigated. Here, we computationally describe DET rates in microtubules, actin filaments and the intermediate filament, vimentin.
View Article and Find Full Text PDFThe impact of sodium nitrite and intermittent fasting on neurofilament and tau protein phosphorylation, and spatial learning in rat hippocampus.
Exp Brain Res
December 2024
Department of Biochemistry and Molecular Biology, College of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang, 471000, P. R. China.
In recent years, the influence of dietary-related factors on neurodegenerative diseases has received considerable attention in the academic community, notably involving the food additive sodium nitrite (NaNO) and intermittent fasting behavior. However, the effects of NaNO and intermittent fasting on spatial learning and memory have not been thoroughly investigated. This study conducted a controlled experiment to explore the impact of NaNO and intermittent fasting on the hyperphosphorylation of hippocampal neurofilament (NF) and tau proteins, as well as spatial learning and memory in rats.
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