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A reproducible framework for monitoring the impact of randomized clinical trials on clinical practice using large-scale real-world data: application to gynaecological surgical trials using the French national healthcare database.
EClinicalMedicine
February 2025
Department of Breast and Gynaecological Surgery, Institut Curie, Paris, France.
Background: Randomized clinical trials (RCTs) are fundamental to evidence-based medicine, but their real-world impact on clinical practice often remains unmonitored. Leveraging large-scale real-world data can enable systematic monitoring of RCT effects. We aimed to develop a reproducible framework using real-world data to assess how major RCTs influence medical practice, using two pivotal surgical RCTs in gynaecologic oncology as an example-the LACC (Laparoscopic Approach to Cervical Cancer) and LION (Lymphadenectomy in Ovarian Neoplasms) trials.
View Article and Find Full Text PDFUsing Evidence-Based Practice in the Transition to Telepractice: Case Study of a Complexity-Based Speech Sound Intervention.
Perspect ASHA Spec Interest Groups
August 2023
School of Speech, Language, and Hearing Sciences, San Diego State University, San Diego, CA.
Purpose: Speech-language pathologists (SLPs) are tasked with integrating the principles of evidence-based practice (EBP) to provide effective and efficient assessment and intervention services that best support clients and their families. As new research, technologies, and perspectives emerge, SLPs are required to adapt their clinical practices to meet these changes while maintaining high-quality evidence-based services. Through an illustrative case study, we aim to demonstrate the process of applying EBP principles - including research evidence, client and family perspectives, and clinical expertise - to a complexity-based speech sound intervention delivered via telepractice.
View Article and Find Full Text PDFEfficacy and Safety of Aprocitentan in the Treatment of Hypertension: A Meta-Analysis of Evidence from Randomized Controlled Trials.
Rev Cardiovasc Med
January 2025
Department of Cardiovascular Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, 100730 Beijing, China.
Background: Hypertension is one of the most prevalent disorders encountered in medical practice, yet effective pharmacotherapy options for resistant hypertension are limited. In this meta-analysis, we aimed to evaluate the efficacy and safety of aprocitentan in treating hypertension.
Methods: We searched PubMed, Embase, ClinicalTrials.
Optimizing Premenopausal Hormone Receptor-Positive Human Epidermal Growth Factor Receptor 2-Negative Early Breast Cancer Management in India: Insights From Expert Consensus.
Cureus
December 2024
Department of Medical Affairs, Dr. Reddy's Laboratories, Hyderabad, IND.
This research aims to optimize adjuvant ovarian function suppression (OFS) for premenopausal Indian women with hormone receptor-positive (HR+) /human epidermal growth factor receptor 2-negative (HER2-) early breast cancer (eBC). To address specific challenges identified in clinical practice, a comprehensive questionnaire consisting of 21 statements was developed. These statements were reviewed and validated by a scientific committee, ensuring their accuracy and relevance to the study's objectives.
View Article and Find Full Text PDFNurses' self-efficacy and outcome expectancy in evidence-based practice: Translation, construct validity and internal consistency of the Dutch scales.
Int J Nurs Stud Adv
June 2025
Radboud Institute for Health Sciences, Scientific Center for Quality of Healthcare (IQ Health), Radboud University Medical Center, Kapittelweg 54, 6525 EP Nijmegen, The Netherlands.
Background: Evidence-based practice (EBP) is crucial for appropriate, effective, and affordable care. Despite EBP education, barriers like low self-efficacy and outcome expectancy limit nurses' engagement in EBP. Reliable scales are essential to evaluate interventions aimed at improving self-efficacy and outcome expectancy in EBP.
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