The PDA Virus Filter Task Force has made significant progress in producing a method that will standardize the nomenclature for virus-removal filters that remove large viruses. A method for preparation of the model bacteriophage, PR 772, has also been produced and will shortly undergo a feasibility study. A technical report on the use of virus removal filters is also being prepared.
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ACS Sens
January 2025
Key Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science, MOE, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China.
Precise and sensitive analysis of specific DNA in actual human bodily fluids is crucial for the early diagnosis of major diseases and for a deeper understanding of DNA functions. Herein, by grafting a peptide-conjugated hairpin DNA probe to a covalent organic framework (COF)-based photocathode, a robust anti-interference photoelectrochemical (PEC) DNA bioassay was explored, which could specifically resist potential interference from nonspecific proteins and reducing species. Human immunodeficiency virus (HIV) DNA was used as the target DNA (tDNA) for the PEC DNA bioassay.
View Article and Find Full Text PDFInt J Pharm
January 2025
Department of Rehabilitation Medicine, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, China. Electronic address:
Ischemic stroke (IS), a prevalent cerebrovascular disorder, is characterized by high morbidity rates and significant disability. However, relevant drug therapy for IS still suffers from limitations such as limited blood-brain barrier (BBB) penetration efficiency, single therapeutic target, short half-life, and strong side effects. The development of multi-target neuroprotective agents using natural drug molecules with low toxicity and combining them with nanotechnology to improve BBB permeability and drug utilization is an important direction in the development of IS therapeutic strategies.
View Article and Find Full Text PDFACS Appl Mater Interfaces
December 2024
School of Chemistry and Chemical Engineering, Xinjiang Normal University, Urumqi 830054, China.
The stratum corneum of the skin functions as a barrier, obstructing drug absorption and complicating the treatment of skin infections caused by pathogens such as bacteria, fungi, and viruses through topical methods. In this research, a microneedle patch was developed, which consists of gelatin-sucrose (SG) that encapsulates polydopamine-copper nanoparticles (PDA@Cu) at the tip for antibacterial purposes. Poly(ethylene glycol) diacrylate (PEGDA) served as the primary substrate for the microneedle shaft (PDA@Cu-SG/PEGDA).
View Article and Find Full Text PDFChem Pharm Bull (Tokyo)
November 2024
Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City.
WHO declared the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus as a global pandemic (coronavirus disease 2019 (COVID-19)) in March 2020. Molnupiravir (MPV) is an oral antiviral drug that received use authorization for mild to moderate COVID-19 treatment in adults. However, the global and national drug testing and research of MPV is still difficult due to lack of standards and validated procedures.
View Article and Find Full Text PDFSci Rep
October 2024
Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, ET-11562, Egypt.
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