Objective: To observe the protective effects of puerarin on radiation injury of experimental rats and to discuss the possible mechanism of its radiation protection.
Methods: Wistar rats were divided randomly into 4 groups with 8 rats in each group: physiological saline non-radiation (SN) group, puerarin non-radiation (PN) group, physiological saline radiation (SR) group, puerarin radiation (PR) group. The source of radiation was cobalt-60 gamma rays, and the rats were exposed to radiation (1.2 Gy/min) at a dose of 18 Gy. Following irradiation of the rats, puerarin was injected intravenously at each dose of 30 mg/kg in 6 consecutive days (24 h interval). Samples were collected and assayed one week later.
Results: Puerarin delayed effectively the declines of the quantity of red blood cells and white blood cells in circulation due to ionizing irradiation, improved the index of thymus and spleen in ionizing irradiation rats, increased the activity of superoxide dismutase (SOD) and decreased the level of malondialdehyde (MDA) in the rat myocardial tissue.
Conclusion: Puerarin has a marked protective effect on ionizing irradiation injury of experimental rats, and its protective mechanism is probably based on oxidation-resistance.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3736/jcim20050113 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A Bacterial Capturing, Neural Network-Like Carbon Nanotubes/Prussian Blue/Puerarin Nanocomposite for Microwave Treatment of Staphylococcus Aureus-Infected Osteomyelitis.
Small
December 2024
School of Materials Science & Engineering, the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China, Tianjin University, Tianjin, 300072, China.
Staphylococcus aureus (S. aureus)-infected osteomyelitis is a deep tissue infection that cannot be effectively treated with antibiotics. Microwave (MW) thermal therapy (MTT) and MW dynamic therapy (MDT) based on MW-responsive materials are promising for the therapy of bacteria-infected osteomyelitis occurring in deep tissues that cannot be effectively treated with antibiotics.
View Article and Find Full Text PDFImproving complexation of puerarin with kudzu starch by various ultrasonic pretreatment: Interaction mechanism analysis.
Ultrason Sonochem
December 2024
Department of Drug Science and Technology, University of Turin, Turin 10125, Italy.
Article Synopsis
- - The industrial process for making kudzu starch often reduces flavonoids like puerarin, so pretreatments such as ultrasonic techniques are important to enhance its biological activity and nutrient interactions.
- - Ultrasonic pretreatment increased the binding of puerarin to kudzu starch and changed the particle size, leading to larger complexes compared to untreated samples, as revealed by various analyses.
- - The study found that ultrasound altered how the starch molecules interacted, creating new hydrogen bonds and resulting in gels with improved properties like higher viscosity and elasticity, showing the potential for more valuable kudzu products.
The Inhibitory Impact of a Co-Assembly Gel with Natural Carrier-Free Binary Small Molecules, as Used in Traditional Chinese Medicine, on the Viability of SW1990 Cells.
Gels
August 2024
Department of Pathophysiology, Hebei University of Chinese Medicine, Shijiazhuang 050000, China.
Chinese herbs are a huge treasure trove of natural products and an important source of many active molecules. The theory of traditional Chinese medicine compatibility (TCMC) is widely applied in clinical practice, but its mechanism is still ambiguous. This study aims to open a new window for this predicament by studying the interaction between the main active ingredients from a drug pair.
View Article and Find Full Text PDFPuerarin inhibits cisplatin-induced ototoxicity in mice through regulation of TRPV1-dependent calcium overload.
Biochem Pharmacol
February 2024
Department of Physiology, Jinzhou Medical University, Jinzhou 121000 PR China. Electronic address:
Puerarin (PUE), a flavonoid derivative with vasodilatory effects found in the traditional Chinese medicine kudzu, has anti-sensorineural hearing loss properties. However, the mechanism of its protective effect against ototoxicity is not well understood. In this study, we used in vitro and in vivo methods to investigate the protective mechanism of puerarin against cisplatin (CDDP)-induced ototoxicity.
View Article and Find Full Text PDFCombined Network Pharmacology and Molecular Docking to Verify the Treatment of Type 2 Diabetes with and .
Comput Math Methods Med
March 2023
Chongqing Medical and Pharmaceutical College, Chongqing 400030, China.
Objective: To explore the potential molecular mechanism of (RP) and (RS) in the treatment of type 2 diabetes mellitus (T2DM) based on network pharmacology and molecular docking.
Methods: The chemical constituents and core targets of RP and RS were searched by Traditional Chinese Medicine System Pharmacology (TCMSP); target genes related to T2DM were obtained through GeneCards database, component target network diagram was constructed, intersection genes of active compounds and T2DM were synthesized, protein-protein interaction (PPI) relationship was obtained, and core targets were screened by using Cytoscape 3.7.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!