AI Article Synopsis

  • The study aimed to determine if serum levels of pregnancy-associated plasma protein A (PAPP-A) are elevated in patients with acute myocardial infarction (AMI).
  • Researchers measured PAPP-A levels in 80 AMI patients and 80 healthy controls, finding no significant difference in levels (1.24 vs. 1.29 mIU/l; P = 0.54).
  • The findings suggest that serum PAPP-A may not be a valuable early indicator for diagnosing AMI.

Article Abstract

Objective: The purpose of this study was to assess whether serum levels of pregnancy-associated plasma protein A (PAPP-A) are elevated early in patients with acute myocardial infarction (AMI).

Design And Methods: We measured serum levels of PAPP-A in 80 patients with AMI and in 80 age-matched healthy control subjects. The mean (+/-SEM) time from onset of symptoms to blood sampling was 6.3 +/- 2.8 h in the group with AMI.

Results: The PAPP-A levels did not differ between the control group and the AMI group (1.24 +/- 0.07 vs. 1.29 +/- 0.02 mIU/l; P = 0.54).

Conclusions: Measurement of serum PAPP-A does not seem to be a useful early marker for AMI.

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Source
http://dx.doi.org/10.1016/j.clinbiochem.2004.10.015DOI Listing

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