A rare case of an unusual association of liver hydatidosis (LH) and beta-thalassemia (beta-Thal) was reported. In a 43 year old white man, who has no connection to endemic areas of echinococcosis or beta-Thal (but was operated probably for splenic echinococcus 25 years ago), an intermediate form of beta-Thal according hematologic morphologic, and hemoglobin-electrophoretic criteria was diagnosed. Common and different criteria to another anemias (especially of iron deficiency) was discussed and authors believed that this splenomegaly (as specific sign of hereditary beta-Thal) isn't indication for operation. Conventional X-ray, US, and CT was characteristic for LH, and intraoperative cytology was performed. Correlation to a very interesting and rare analogous case, but of homozygous hemoglobinopathy C was made.

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