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Fertility Preservation in More than 7000 Male Patients: A Single-Center, Tertiary Care Registry Study over 30 Years.
Cancers (Basel)
February 2025
Department of Medicine, University of Padua, 35128 Padova, Italy.
: Semen cryopreservation has been widely used in recent decades, mainly in patients with male factor infertility (MFI) and patients with cancer (to preserve their fertility potential before undergoing gonadotoxic treatments, such as chemotherapy or radiotherapy). : we evaluated the temporal trend and the existence of factors determining the usage of cryopreserved semen (in order, for instance, to conceive using assisted reproduction techniques (ARTs)). We evaluated 7044 patients who cryopreserved since 1991, evaluating clinical information such as the diagnosis, age, the method with which the collection took place and the number of pick-ups for use in ART.
View Article and Find Full Text PDFIntroduction: Hip hemiarthroplasty is a common procedure for femoral neck fractures in the geriatric population. Immediate implant-related complications such as dislocation, periprosthetic fracture, and leg length discrepancy are uncommon, but should be ruled out with the use of post-operative X-rays. There is some debate as to the timing of the post-operative X-rays.
View Article and Find Full Text PDFUsing data to drive programmatic change: Recalculating NCLEX-RN success.
J Prof Nurs
February 2025
Department of Social & Behavioral Sciences, Colorado Mesa University, United States of America. Electronic address:
Background: Nursing schools admit students who are highly qualified using a variety of admission criteria. Even when picking top achievers, it does not guarantee NCLEX-RN success. Nursing programs too often maintain outdated or unvalidated admission processes.
View Article and Find Full Text PDFMulti-omics analysis reveals the sensitivity of immunotherapy for unresectable non-small cell lung cancer.
Front Immunol
February 2025
Department of Respiratory and Critical Care Medicine, Changzheng Hospital, Navy Medical University, Shanghai, China.
Background: To construct a prediction model consisting of metabolites and proteins in peripheral blood plasma to predict whether patients with unresectable stage III and IV non-small cell lung cancer can benefit from immunotherapy before it is administered.
Methods: Peripheral blood plasma was collected from unresectable stage III and IV non-small cell lung cancer patients who were negative for driver mutations before receiving immunotherapy. Then we classified samples according to the follow-up results after two courses of immunotherapy and non-targeted metabolomics and proteomics analyses were performed to select different metabolites and proteins.
The underappreciated contribution of Oskar Fischer to the knowledge of Frontotemporal Lobar Degeneration.
Dement Neuropsychol
February 2025
University of California, Department of Neurology and Pathology, San Francisco CA, USA.
Frontotemporal Lobar Degeneration (FTLD) encompasses progressive neurodegeneration primarily affecting the frontal and/or temporal lobes, presenting in varied pathological entities. These pathologies lead to diverse clinical syndromes collectively known as Frontotemporal Dementia (FTD), which includes a behavioral variant, and primary progressive aphasia, with its non-fluent and semantic variants, and related conditions with parkinsonism or motoneuron disease features. The historical development of FTD concept is rooted in the pioneering work of Arnold Pick, who first described clinical cases of focal brain atrophy.
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