AI Article Synopsis
- Protein splicing is a process that involves intein, a polypeptide, catalyzing its own removal from a pre-protein while simultaneously joining the surrounding polypeptides (exteins) together.
- This mechanism includes a series of reactions where intramolecular cleavage and ligation occur.
- Protein splicing enhances our understanding of posttranslational processing and has promising applications in various biotechnological fields.
Article Abstract
Protein splicing, which is an intein mediated posttranslational processing, involves a series of intramolecular cleavage-ligation reactions. Intein is an intervening polypeptide which can catalytic self-cleavage from a pre-protein accompanied by the concomitant joining of the two flanking polypeptides (the extein) through a peptide bond. Protein splicing not only enriches genetic theory of posttranslational processing, but also have wide application prospect.
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