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An Atypical Acyl-CoA Synthetase Enables Efficient Biosynthesis of Extender Units for Engineering a Polyketide Carbon Scaffold.
Angew Chem Int Ed Engl
October 2022
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, 1 Luojiashan Rd., Wuhan, 430071, China.
Article Synopsis
- * Researchers discovered a unique ACS (UkaQ) that lacks a critical regulatory residue, allowing it to efficiently work with a variety of substrates.
- * After engineering UkaQ to enhance its stability and activity, they successfully used it to create diverse acyl-CoAs and synthesize novel antimycin analogues, advancing the potential for natural product biosynthesis.
Residue analysis of fungicides fenpicoxamid, isofetamid, and mandestrobin in cereals using zirconium oxide disposable pipette extraction clean-up and ultrahigh-performance liquid chromatography-tandem mass spectrometry.
J Chromatogr A
June 2020
Laboratory of Quality & Safety Risk Assessment for Ginseng and Antler Products, Jilin Agricultural University, Changchun, Jilin 130118, China. Electronic address:
In the present study, a fast multiresidue method determining three novel fungicides fenpicoxamid, isofetamid, and mandestrobin in cereals was developed and validated for the first time using ultrahigh-performance liquid chromatography coupled to tandem mass spectrometry (UHPLC-MS/MS). Samples were extracted by QuEChERS (Quick, Easy, Cheap, Effective, Rugged, and Safe) methodology, and cleaned up using the disposable pipette extraction (DPX) tips containing primary secondary amine (PSA) and silica gel modified with zirconium oxide (Z-Sep) in less than 1 min. Linearity (r > 0.
View Article and Find Full Text PDFUnravelling the Biosynthetic Flexibility of UK-2A Enables Enzymatic Synthesis of Its Structural Variants.
ACS Synth Biol
December 2019
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery Ministry of Education, School of Pharmaceutical Sciences , Wuhan University, Wuhan 430071 , China.
Emerging antimicrobial resistant fungal pathogens are a growing threat, and fungicides with novel modes of action are urgently needed to prevent critical failures in global food security. Fenpicoxamid, the prodrug of UK-2A, is a member of a new class of antifungal agents that displays no cross-resistance to other fungicides. Rational engineering of its structure using a biosynthetic approach is a promising avenue for developing more potent fungicides.
View Article and Find Full Text PDFBiological characterization of fenpicoxamid, a new fungicide with utility in cereals and other crops.
Pest Manag Sci
October 2017
Dow AgroSciences LLC, Zionsville Rd, Indianapolis, IN, USA.
Background: The development of novel highly efficacious fungicides that lack cross-resistance is extremely desirable. Fenpicoxamid (Inatreq™ active) possesses these characteristics and is a member of a novel picolinamide class of fungicides derived from the antifungal natural product UK-2A.
Results: Fenpicoxamid strongly inhibited in vitro growth of several ascomycete fungi, including Zymoseptoria tritici (EC , 0.
[Recent advances in the study of antifungal lead compounds with new chemical scaffolds].
Yao Xue Xue Bao
November 2007
School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
In recent years, the incidence of infections caused by invasive fungal pathogens has increased dramatically. However, most antifungal agents used in clinic have many drawbacks and cannot meet the demand of the clinical use. Therefore, for the development of new generation of antifungal agents, it is of great significance to find antifungal lead compounds with novel chemical scaffolds and new mode of action.
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