Epidural clonidine-fentanyl combination for labour analgesia: a comparison with bupivacaine-fentanyl.

This open study of 20 women compared epidural clonidine (300 microg)/fentanyl (100 microg) with bupivacaine (25 mg)/fentanyl (100 microg) in the provision of pain relief in labour. Sensory tests in the clonidine group revealed slight alterations in the appreciation of pin prick and temperature but motor power was unchanged. Analgesia after the first dose was similar in the two groups, but thereafter the analgesia provided by clonidine/fentanyl was less than that from bupivacaine/fentanyl. Despite the incomplete pain relief provided by clonidine/fentanyl, mothers appreciated their essentially normal sensations and muscle power. Midwives also commented favourably on the normal mobility of these labouring mothers. There was no difference between the two groups in the duration of labour or the condition of the infants.