AI Article Synopsis
- Piper nigrum (black pepper) is widely used in Ayurvedic medicine for its antibacterial properties.
- The petroleum ether extract of its berries led to the discovery of five compounds, including two (pergumidiene and trachyone) which are being reported for the first time.
- All isolated compounds demonstrated antibacterial activity against various Gram-positive and Gram-negative bacteria, highlighting their potential in medical applications.
Article Abstract
Piper nigrum finds an extensive application in antibacterial preparations belonging to Ayurvedic system of medicine. A bioguided extraction and fractionation of the petroleum ether extract of the berries of P. nigrum afforded 2E, 4E, 8Z-N-isobutyleicosatrienamide (1), pellitorine (2), trachyone (3), pergumidiene (4) and isopiperolein B (5). Pergumidiene and trachyone are isolated for the first time from P. nigrum. All the isolated compounds were active against Bacillus subtilis, Bacillus sphaericus, and Staphylococcus aureus amongst Gram + ve bacteria, and Klebsiella aerogenes and Chromobacterium violaceum among Gram -ve bacterial strains.
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| http://dx.doi.org/10.1016/j.phymed.2003.04.004 | DOI Listing |
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