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Antiproliferative constituents from Umbelliferae plants VII. Active triterpenes and rosmarinic acid from Centella asiatica. | LitMetric
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Antiproliferative constituents from Umbelliferae plants VII. Active triterpenes and rosmarinic acid from Centella asiatica.

Miyako Yoshida Masahiro Fuchigami Tsuneatsu Nagao Hikaru Okabe Kazuhisa Matsunaga Jiro Takata Yoshiharu Karube Ryota Tsuchihashi Junei Kinjo Kunihide Mihashi Toshihiro Fujioka

Biol Pharm Bull

Faculty of Pharmaceutical Sciences, Fukuoka University, Japan.

Published: January 2005

The antiproliferative constituents in the MeOH extract from the aerial parts of Centella asiatica were investigated. Activity-guided fractionation of MeOH extract resulted in the isolation of ursolic acid lactone, ursolic acid, pomolic acid, 2alpha,3alpha-dihydroxyurs-12-en-28-oic acid, 3-epimaslinic acid, asiatic acid, corosolic acid, and rosmarinic acid. Antiproliferative activity of the isolated compounds against human gastric adenocarcinoma (MK-1), human uterine carcinoma (HeLa), and murine melanoma (B16F10) cells was estimated.

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http://dx.doi.org/10.1248/bpb.28.173DOI Listing

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